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EBI PDBe PDBeView

PDBe Entry: 3c0z view

Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with SAHA
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.1 Å, R-factor: 19.903%, Free R-factor: 24.291%, Spacegroup: P 32
Released 19/02/2008, deposition: 21/01/2008, last revision: 27/10/2009
Authors Min, J.search; Schuetz, A.search; Loppnau, P.search; Weigelt, J.search; Sundstrom, M.search; Arrowsmith, C.H.search; Edwards, A.M.search; Bochkarev, A.search; Plotnikov, A.N.search; Structural Genomics Consortium (SGC)search
Primary citation Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.BIOL.CHEM.search vol:283, pag:11355-11363 (2008) [PubMed ID 18285338 ]search
Keywords HDACsearch, STRUCTURAL GENOMICSsearch, STRUCTURAL GENOMICS CONSORTIUMsearch, SGCsearch, Alternative splicingsearch, Chromatin regulatorsearch, Cytoplasmsearch, Hydrolasesearch, Nucleussearch, Phosphoproteinsearch, Polymorphismsearch, Repressorsearch, Transcriptionsearch, Transcription regulationsearch
EC 3.5.1.98 ExPASy BRENDA search (A B C)
Organism Homo sapiens(human) 9606search(A B C)
UniProt Histone deacetylase 7 (EC 3.5.1.98) (HD7) (HD7a) Q8WUI4search (A B C)
Solvent A, B, C
Related entries 2nvr, 3c0y, 3c10
Polymers
Id Name Type UniProt Residues Observed
A, B, C Histone deacetylase 7a Protein Q8WUI4 (HDAC7_HUMAN)search
 423 90%
Heterogens
Id Name Ligands
A, B, C ZINC ION ZN search
A, B, C POTASSIUM ION K search
A, B, C OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE SHH search
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