3c0i Summary

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CASK CaM-Kinase Domain- 3'-AMP complex, P212121 form

The structure was published by Mukherjee, K., Sharma, M., Urlaub, H., et al., Jahn, R., Sudhof, T.C., and Wahl, M.C., in 2008 in a paper entitled "CASK Functions as a Mg2+-independent neurexin kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Peripheral plasma membrane protein CASK. This molecule has the UniProt identifier O14936 (CSKP_HUMAN)search. The sample contained 351 residues which is < 90% of the natural sequence. Out of 351 residues 298 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peripheral plasma membrane protein CASK O14936 (1-337) (CSKP_HUMAN)search Homo sapienssearch < 90% 351 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14936 (1 - 337) Peripheral plasma membrane protein CASK Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (O14936) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Protein kinase-like domainsearch