3c09 Summary

pdbe.org/3c09
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Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR

The structure was published by Schmiedel, J., Blaukat, A., Li, S., Knochel, T., and Ferguson, K.M., in 2008 in a paper entitled "Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Matuzumab Fab Light chain, Matuzumab Fab Heavy chain, and Epidermal growth factor receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Matuzumab Fab Light chain Not available
Homo sapienssearch, Mus musculussearch Not available 212 99%
B Matuzumab Fab Light chain Not available
Homo sapienssearch, Mus musculussearch Not available 212 99%
H Matuzumab Fab Heavy chain Not available
Homo sapienssearch, Mus musculussearch Not available 223 96%
C Matuzumab Fab Heavy chain Not available
Homo sapienssearch, Mus musculussearch Not available 223 96%
A Epidermal growth factor receptor P00533 (336-538) (EGFR_HUMAN)search Homo sapienssearch < 90% 214 89%
D Epidermal growth factor receptor P00533 (336-538) (EGFR_HUMAN)search Homo sapienssearch < 90% 214 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00533 (336 - 538) Epidermal growth factor receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L, B Immunoglobulinssearch
H, C V set domains (antibody variable domain-like)search, C1 set domains (antibody constant domain-like)search Immunoglobulinssearch
A, D L domainsearch, Growth factor receptor domainsearch 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch

Chain ID Cellular component (GO)
A, D (P00533) membranesearch

Chain InterPro annotation
L, B Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H, C Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
A, D Receptor L-domainsearch Furin-like repeatsearch