Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR
The structure was published by Schmiedel, J., Blaukat, A., Li, S., Knochel, T., and Ferguson, K.M., in 2008 in a paper entitled "Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 3 biomacromolecules, namely Matuzumab Fab Light chain, Matuzumab Fab Heavy chain, and Epidermal growth factor receptor.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: