Crystal Structure Analysis of Focal Adhesion Kinase with a Methanesulfonamide Diaminopyrimidine Inhibitor
The structure was published by Roberts, W.G., Ung, E., Whalen, P., et al., Marr, E., Griffor, M., and Vajdos, F., in 2008 in a paper entitled "Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Focal adhesion kinase 1. This molecule has the UniProt identifier Q05397 (FAK1_HUMAN). The sample contained 276 residues which is < 90% of the natural sequence. Out of 276 residues 258 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: