co-crystal structure of Lck and aminopyrimidine reverse amide 23
The structure was published by DiMauro, E.F., Newcomb, J., Nunes, J.J., et al., Zhao, H., Zhu, L., and Zhu, X., in 2008 in a paper entitled "Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2008.
The experimental data on which the structure is based was not deposited.
The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase LCK. This molecule has the UniProt identifier P06239 (LCK_HUMAN). The sample contained 277 residues which is < 90% of the natural sequence. Out of 277 residues 254 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):