3bxl Summary

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Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex

A publication describing this structure is not available. The depositing authors are Mori, M.X.search; Vander Kooi, C.W.search; Leahy, D.J.search; Yue, D.T.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calmodulin and Voltage-dependent R-type calcium channel subunit alpha-1E peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62161 (2-149) (CALM_RAT)search Rattus norvegicussearch 98% 148 97%
B Voltage-dependent R-type calcium channel subunit alpha-1E peptide Q15878 (1867-1887) (CAC1E_HUMAN)search Homo sapienssearch < 90% 21 80%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62161 (2 - 149) Calmodulin Rattus norvegicus
Q15878 (1867 - 1887) Voltage-dependent R-type calcium channel subunit alpha-1E peptide

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P62161) Calmodulin-likesearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
B Voltage gated calcium channel IQ domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62161) calcium ion bindingsearch protein bindingsearch calcium-dependent protein bindingsearch phospholipase bindingsearch ion channel bindingsearch nitric-oxide synthase bindingsearch type 3 metabotropic glutamate receptor bindingsearch protein phosphatase activator activitysearch protein domain specific bindingsearch N-terminal myristoylation domain bindingsearch titin bindingsearch metal ion bindingsearch enzyme regulator activitysearch calcium channel regulator activitysearch adenylate cyclase bindingsearch phosphatidylinositol 3-kinase bindingsearch nitric-oxide synthase regulator activitysearch thioesterase bindingsearch protein N-terminus bindingsearch cytoplasmsearch nucleussearch spindlesearch spindle microtubulesearch spindle polesearch neuron projectionsearch cytoskeletonsearch extracellular vesicular exosomesearch sarcomeresearch cytosolsearch nucleoplasmsearch growth conesearch calcium channel complexsearch plasma membranesearch centrosomesearch response to amphetaminesearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch positive regulation of nitric-oxide synthase activitysearch positive regulation of protein dephosphorylationsearch positive regulation of phosphoprotein phosphatase activitysearch calcium-mediated signalingsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of store-operated calcium channel activitysearch response to calcium ionsearch response to corticosteronesearch activation of adenylate cyclase activitysearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch detection of calcium ionsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch regulation of heart ratesearch positive regulation of cyclic nucleotide metabolic processsearch regulation of high voltage-gated calcium channel activitysearch substantia nigra developmentsearch regulation of cardiac muscle contractionsearch regulation of cytokinesissearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B Voltage-dependent calcium channel, alpha-1 subunit, IQ domainsearch