3bxl Summary

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Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin complex

A publication describing this structure is not available. The depositing authors are Mori, M.X.search; Vander Kooi, C.W.search; Leahy, D.J.search; Yue, D.T.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calmodulin and Voltage-dependent R-type calcium channel subunit alpha-1E peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62161 (2-149) (CALM_RAT)search Rattus norvegicussearch 98% 148 97%
B Voltage-dependent R-type calcium channel subunit alpha-1E peptide Q15878 (1867-1887) (CAC1E_HUMAN)search Homo sapienssearch < 90% 21 80%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62161 (2 - 149) Calmodulin Rattus norvegicus
Q15878 (1867 - 1887) Voltage-dependent R-type calcium channel subunit alpha-1E peptide

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P62161) Calmodulin-likesearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
B Voltage gated calcium channel IQ domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62161) N-terminal myristoylation domain bindingsearch type 3 metabotropic glutamate receptor bindingsearch protein domain specific bindingsearch calcium ion bindingsearch calcium-dependent protein bindingsearch protein bindingsearch phosphatidylinositol 3-kinase bindingsearch nitric-oxide synthase regulator activitysearch metal ion bindingsearch adenylate cyclase bindingsearch protein N-terminus bindingsearch ion channel bindingsearch nitric-oxide synthase bindingsearch phospholipase bindingsearch thioesterase bindingsearch titin bindingsearch protein phosphatase activator activitysearch calcium channel regulator activitysearch enzyme regulator activitysearch regulation of cytokinesissearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch positive regulation of phosphoprotein phosphatase activitysearch regulation of cardiac muscle contractionsearch positive regulation of cyclic nucleotide metabolic processsearch positive regulation of nitric-oxide synthase activitysearch response to amphetaminesearch response to corticosteronesearch calcium-mediated signalingsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of store-operated calcium channel activitysearch positive regulation of protein dephosphorylationsearch substantia nigra developmentsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch regulation of heart ratesearch regulation of high voltage-gated calcium channel activitysearch detection of calcium ionsearch response to calcium ionsearch activation of adenylate cyclase activitysearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch spindle polesearch plasma membranesearch cytoplasmsearch neuron projectionsearch spindle microtubulesearch centrosomesearch cytoskeletonsearch nucleussearch extracellular vesicular exosomesearch calcium channel complexsearch cytosolsearch sarcomeresearch growth conesearch spindlesearch nucleoplasmsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B Voltage-dependent calcium channel, alpha-1 subunit, IQ domainsearch