3bxk Summary

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Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex

A publication describing this structure is not available. The depositing authors are Mori, M.X.search; Vander Kooi, C.W.search; Leahy, D.J.search; Yue, D.T.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.55 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calmodulin and Voltage-dependent P/Q-type calcium channel subunit alpha-1A peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calmodulin P62161 (2-149) (CALM_RAT)search Rattus norvegicussearch 98% 148 95%
C Calmodulin P62161 (2-149) (CALM_RAT)search Rattus norvegicussearch 98% 148 95%
B Voltage-dependent P/Q-type calcium channel subunit alpha-1A peptide O00555 (1955-1975) (CAC1A_HUMAN)search Homo sapienssearch < 90% 21 90%
D Voltage-dependent P/Q-type calcium channel subunit alpha-1A peptide O00555 (1955-1975) (CAC1A_HUMAN)search Homo sapienssearch < 90% 21 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62161 (2 - 149) Calmodulin Rattus norvegicus
O00555 (1955 - 1975) Voltage-dependent P/Q-type calcium channel subunit alpha-1A peptide

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C (P62161) Calmodulin-likesearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
B, D Voltage gated calcium channel IQ domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P62161) calcium ion bindingsearch calcium-dependent protein bindingsearch enzyme regulator activitysearch nitric-oxide synthase bindingsearch protein bindingsearch protein domain specific bindingsearch phosphatidylinositol 3-kinase bindingsearch nitric-oxide synthase regulator activitysearch ion channel bindingsearch titin bindingsearch type 3 metabotropic glutamate receptor bindingsearch calcium channel regulator activitysearch thioesterase bindingsearch N-terminal myristoylation domain bindingsearch protein phosphatase activator activitysearch phospholipase bindingsearch protein N-terminus bindingsearch metal ion bindingsearch adenylate cyclase bindingsearch positive regulation of phosphoprotein phosphatase activitysearch positive regulation of protein dephosphorylationsearch activation of adenylate cyclase activitysearch regulation of high voltage-gated calcium channel activitysearch substantia nigra developmentsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch response to corticosteronesearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch positive regulation of cyclic nucleotide metabolic processsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch detection of calcium ionsearch regulation of store-operated calcium channel activitysearch response to amphetaminesearch calcium-mediated signalingsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of cardiac muscle contractionsearch regulation of cytokinesissearch regulation of heart ratesearch response to calcium ionsearch positive regulation of nitric-oxide synthase activitysearch cytoplasmsearch spindle microtubulesearch nucleussearch cytoskeletonsearch extracellular vesicular exosomesearch nucleoplasmsearch calcium channel complexsearch centrosomesearch spindlesearch spindle polesearch growth conesearch neuron projectionsearch sarcomeresearch plasma membranesearch cytosolsearch

Chain InterPro annotation
A, C EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B, D Voltage-dependent calcium channel, alpha-1 subunit, IQ domainsearch