3bx5 Summary


P38 alpha map kinase complexed with BMS-640994

The structure was published by Hynes, J., Wu, H., Pitt, S., et al., Barrish, J.C., Dodd, J., and Leftheris, K., in 2008 in a paper entitled "The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 337 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor 2 signaling pathwaysearch osteoclast differentiationsearch innate immune responsesearch DNA damage checkpointsearch fatty acid oxidationsearch vascular endothelial growth factor receptor signaling pathwaysearch glucose metabolic processsearch positive regulation of blood vessel endothelial cell migrationsearch signal transductionsearch regulation of transcription, DNA-templatedsearch transcription, DNA-templatedsearch peptidyl-serine phosphorylationsearch positive regulation of myotube differentiationsearch toll-like receptor 4 signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch RNA metabolic processsearch toll-like receptor 5 signaling pathwaysearch positive regulation of protein import into nucleussearch response to muramyl dipeptidesearch MyD88-dependent toll-like receptor signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch signal transduction in response to DNA damagesearch cellular response to lipopolysaccharidesearch positive regulation of erythrocyte differentiationsearch stress-induced premature senescencesearch activation of MAPK activitysearch response to stresssearch toll-like receptor TLR1:TLR2 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch cellular response to DNA damage stimulussearch Ras protein signal transductionsearch chondrocyte differentiationsearch mRNA metabolic processsearch cellular response to vascular endothelial growth factor stimulussearch muscle cell differentiationsearch positive regulation of myoblast differentiationsearch cartilage condensationsearch striated muscle cell differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch positive regulation of myoblast fusionsearch stress-activated MAPK cascadesearch intracellular signal transductionsearch cellular response to ionizing radiationsearch chemotaxissearch p38MAPK cascadesearch cell morphogenesissearch response to lipopolysaccharidesearch skeletal muscle tissue developmentsearch angiogenesissearch phosphorylationsearch cell surface receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch blood coagulationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch MAPK cascadesearch 3'-UTR-mediated mRNA stabilizationsearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor 3 signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch cellular component movementsearch apoptotic processsearch positive regulation of reactive oxygen species metabolic processsearch gene expressionsearch platelet activationsearch ATP bindingsearch protein kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein serine/threonine kinase activitysearch nucleotide bindingsearch NFAT protein bindingsearch kinase activitysearch MAP kinase kinase activitysearch transferase activitysearch nucleoplasmsearch cytosolsearch nucleussearch cytoplasmsearch cellsearch spindle polesearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch