3bv2 Summary


Morpholino pyrrolotriazine P38 Alpha map kinase inhibitor compound 30

The structure was published by Wrobleski, S.T., Lin, S., Hynes, J., et al., Barrish, J.C., Schieven, G.L., and Leftheris, K., in 2008 in a paper entitled "Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 337 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein kinase activitysearch protein bindingsearch MAP kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch NFAT protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch kinase activitysearch MAP kinase kinase activitysearch protein phosphorylationsearch osteoclast differentiationsearch positive regulation of protein import into nucleussearch peptidyl-serine phosphorylationsearch skeletal muscle tissue developmentsearch response to stresssearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of myotube differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to ionizing radiationsearch chondrocyte differentiationsearch platelet activationsearch transcription, DNA-templatedsearch p38MAPK cascadesearch positive regulation of myoblast fusionsearch toll-like receptor 3 signaling pathwaysearch RNA metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch response to lipopolysaccharidesearch cellular component movementsearch cartilage condensationsearch positive regulation of erythrocyte differentiationsearch toll-like receptor 4 signaling pathwaysearch signal transductionsearch Ras protein signal transductionsearch lipopolysaccharide-mediated signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of myoblast differentiationsearch gene expressionsearch MyD88-dependent toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch regulation of transcription from RNA polymerase II promotersearch intracellular signal transductionsearch mRNA metabolic processsearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of muscle cell differentiationsearch cell surface receptor signaling pathwaysearch apoptotic processsearch toll-like receptor 5 signaling pathwaysearch angiogenesissearch innate immune responsesearch muscle cell differentiationsearch positive regulation of reactive oxygen species metabolic processsearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of transcription, DNA-templatedsearch glucose metabolic processsearch activation of MAPK activitysearch toll-like receptor signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch cellular response to vascular endothelial growth factor stimulussearch fatty acid oxidationsearch cell morphogenesissearch neurotrophin TRK receptor signaling pathwaysearch phosphorylationsearch toll-like receptor 10 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch negative regulation of canonical Wnt signaling pathwaysearch blood coagulationsearch DNA damage checkpointsearch response to muramyl dipeptidesearch vascular endothelial growth factor receptor signaling pathwaysearch stress-activated MAPK cascadesearch striated muscle cell differentiationsearch cellular response to DNA damage stimulussearch cellular response to lipopolysaccharidesearch signal transduction in response to DNA damagesearch chemotaxissearch nucleoplasmsearch cytosolsearch cytoplasmsearch nucleussearch extracellular vesicular exosomesearch spindle polesearch mitochondrionsearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch