3bun Summary details

pdbe.org/3bun/summary_details
spacer Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4
Summary
Header LIGASE/SIGNALING PROTEINsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.0 Å, R-factor: 20.1%, Free R-factor: 24.2%, Spacegroup: P 6
Released 26/02/2008, deposition: 03/01/2008, last revision: 24/02/2009
Authors Ng, C.search; Jackson, R.A.search; Buschdorf, J.P.search; Sun, Q.search; Guy, G.R.search; Sivaraman, J.search
Primary citation Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
EMBO J.search vol:27, pag:804-816 (2008) [PubMed 18273061 ]search
Keywords Cblsearch, TKBsearch, ligasesearch, signal transductionsearch, proto-oncogenesearch, complexsearch, Developmental proteinsearch, Membranesearch, Metal-bindingsearch, Phosphoproteinsearch, SH2 domainsearch, Ubl conjugation pathwaysearch, Zinc-fingersearch, LIGASE-SIGNALING PROTEIN COMPLEXsearch
EC 6.3.2.- ExPASy BRENDA search (B)
Organism Homo sapiens(human) 9606search(B)
UniProt Q9C004search (A)
P22681search (B)
Solvent A, B
Related entries 3bum, 3buo, 3buw, 3bux
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A 13-meric peptide from Portein sprouty homolog 4 Protein Q9C004 (SPY4_HUMAN)search
13 53%
B E3 ubiquitin-protein ligase CBL Protein P22681 (CBL_HUMAN)search
329 92%
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