3bu6 Summary


Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB phosphopeptide

The structure was published by Wu, J., Tseng, Y.D., Xu, C.F., Neubert, T.A., White, M.F., and Hubbard, S.R., in 2008 in a paper entitled "Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely insulin receptor subunit beta and Insulin receptor substrate 2.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A insulin receptor subunit beta P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 306 97%
B Insulin receptor substrate 2 P81122 (620-634) (IRS2_MOUSE)search Mus musculussearch < 90% 15 93%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06213 (1005 - 1310) insulin receptor subunit beta Homo sapiens
P81122 (620 - 634) Insulin receptor substrate 2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P06213) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch transmembrane receptor protein tyrosine kinase activitysearch protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch