3bta Summary

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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A

The structure was published by Lacy, D.B., Tepp, W., Cohen, A.C., DasGupta, B.R., and Stevens, R.C., in 1998 in a paper entitled "Crystal structure of botulinum neurotoxin type A and implications for toxicity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PROTEIN (BOTULINUM NEUROTOXIN TYPE A). This molecule has the UniProt identifier P10845 (BXA1_CLOBO)search. The sample contained 1295 residues which is 100% of the natural sequence. Out of 1295 residues 1276 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (BOTULINUM NEUROTOXIN TYPE A) P10845 (2-1296) (BXA1_CLOBO)search Clostridium botulinumsearch 100% 1295 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10845 (2 - 1296) PROTEIN (BOTULINUM NEUROTOXIN TYPE A) Clostridium botulinum

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P10845) Clostridium neurotoxins, the second last domainsearch, Clostridium neurotoxins, C-terminal domainsearch, Clostridium neurotoxins, catalytic domainsearch, Clostridium neurotoxins, "coiled-coil" domainsearch PF01742: Clostridial neurotoxin zinc proteasesearch, PF07951: Clostridium neurotoxin, C-terminal receptor bindingsearch, PF07952: Clostridium neurotoxin, Translocation domainsearch, PF07953: Clostridium neurotoxin, N-terminal receptor bindingsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P10845) pathogenesissearch inhibition of neurotransmitter uptakesearch synaptic transmissionsearch proteolysissearch neurotransmitter secretionsearch integral component of membranesearch extracellular regionsearch host cell plasma membranesearch membranesearch host cell junctionsearch host cell presynaptic membranesearch host cell cytosolsearch host cell membranesearch host cell cytoplasmsearch host cell synapsesearch protein bindingsearch metalloendopeptidase activitysearch metal ion bindingsearch metallopeptidase activitysearch hydrolase activitysearch peptidase activitysearch toxin receptor bindingsearch zinc ion bindingsearch

Chain InterPro annotation
A Botulinum neurotoxin/Tetanus toxinsearch Kunitz inhibitor ST1-likesearch Clostridium neurotoxin, translocationsearch Clostridium neurotoxin, receptor binding N-terminalsearch Clostridium neurotoxin, receptor-binding C-terminalsearch Concanavalin A-like lectin/glucanase domainsearch