Function and Biology

NEMO/IKKb association domain structure

Source organism: Homo sapiens
Biochemical function: IkappaB kinase activity
Biological process: not assigned
Cellular component: not assigned

EC 2.7.11.10: I-kappa-B kinase

Reaction catalysed:
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]
Systematic name:
ATP:[I-kappa-B protein] phosphotransferase
Alternative Name(s):
  • CHUK
  • IKBKA
  • IKBKB
  • IKK
  • IKK-1
  • IKK-2
  • Inhibitor of NF-kappa-B kinase
  • Inhibitor of NF-kappa-B kinase
  • STK12
  • TANK-binding kinase 1
  • TBK1

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF11577
Domain description: NF-kappa-B essential modulator NEMO
Occurring in:
  1. NF-kappa-B essential modulator
The deposited structure of PDB entry 3brv contains 2 copies of Pfam domain PF11577 (NF-kappa-B essential modulator NEMO) in NF-kappa-B essential modulator. Showing 1 copy in chain D.

PF12179
Domain description: I-kappa-kinase-beta NEMO binding domain
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit beta
The deposited structure of PDB entry 3brv contains 2 copies of Pfam domain PF12179 (I-kappa-kinase-beta NEMO binding domain) in Inhibitor of nuclear factor kappa-B kinase subunit beta. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR022007
Domain description: I-kappa-kinase-beta NEMO binding domain
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit beta
IPR021063
Domain description: NF-kappa-B essential modulator NEMO, N-terminal
Occurring in:
  1. NF-kappa-B essential modulator

Structure domains

CATH CATH domains
1.20.5.390
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: L1 transposable element, trimerization domain
Occurring in:
  1. NF-kappa-B essential modulator
The deposited structure of PDB entry 3brv contains 2 copies of CATH domain 1.20.5.390 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in NF-kappa-B essential modulator. Showing 1 copy in chain D.
6.10.250.2110
Class: Special
Architecture: Helix non-globular
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Inhibitor of nuclear factor kappa-B kinase subunit beta
The deposited structure of PDB entry 3brv contains 1 copy of CATH domain 6.10.250.2110 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Inhibitor of nuclear factor kappa-B kinase subunit beta. Showing 1 copy in chain C.