3brt Summary

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NEMO/IKK association domain structure

The structure was published by Rushe, M., Silvian, L., Bixler, S., et al., Guckian, K., Pellegrini, M., and Lugovskoy, A., in 2008 in a paper entitled "Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Inhibitor of nuclear factor kappa-B kinase subunit beta,Inhibitor of nuclear factor kappa-B kinase subunit alpha and NF-kappa-B essential modulator.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Inhibitor of nuclear factor kappa-B kinase subunit beta,Inhibitor of nuclear factor kappa-B kinase subunit alpha O14920 (701-730) (IKKB_HUMAN)search ,
O15111 (732-745) (IKKA_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
47 91%
C Inhibitor of nuclear factor kappa-B kinase subunit beta,Inhibitor of nuclear factor kappa-B kinase subunit alpha O14920 (701-730) (IKKB_HUMAN)search ,
O15111 (732-745) (IKKA_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
47 91%
B NF-kappa-B essential modulator Q9Y6K9 (44-111) (NEMO_HUMAN)search Homo sapienssearch < 90% 68 91%
D NF-kappa-B essential modulator Q9Y6K9 (44-111) (NEMO_HUMAN)search Homo sapienssearch < 90% 68 91%


Chain Sequence family (Pfam)
A, C I-kappa-kinase-beta NEMO binding domainsearch
B, D NF-kappa-B essential modulator NEMOsearch

Chain ID Molecular function (GO)
A, C (O14920O15111) IkappaB kinase activitysearch

Chain InterPro annotation
A, C I-kappa-kinase-beta NEMO binding domainsearch
B, D NF-kappa-B essential modulator NEMO, N-terminalsearch