3brd Summary

pdbe.org/3brd
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CSL (Lag-1) bound to DNA with Lin-12 RAM peptide, P212121

The structure was published by Friedmann, D.R., Wilson, J.J., and Kovall, R.A., in 2008 in a paper entitled "RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.21 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This entry contains 17 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Lin-12 and glp-1 phenotype protein 1, isoform a Q8MXE7 (190-661) (Q8MXE7_CAEEL)search Caenorhabditis eleganssearch < 90% 477 89%
D Protein lin-12 P14585 (930-957) (LIN12_CAEEL)search Caenorhabditis eleganssearch < 90% 29 51%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8MXE7 (190 - 661) Lin-12 and glp-1 phenotype protein 1, isoform a Caenorhabditis elegans
P14585 (930 - 957) Protein lin-12 Caenorhabditis elegans

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A NF-kappa-B/REL/DORSAL transcription factors, C-terminal domainsearch, DNA-binding protein LAG-1 (CSL)search Lin-12 and glp-1 transcriptional regulator; domain 1search, Trefoil (Acidic Fibroblast Growth Factor, subunit A)search, Immunoglobulinssearch Beta-trefoil DNA-binding domainsearch, LAG1, DNA bindingsearch
D

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q8MXE7) regulation of transcription, DNA-templatedsearch RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch RNA polymerase II core promoter proximal region sequence-specific DNA bindingsearch nucleussearch

Chain InterPro annotation
A IPT domainsearch p53-like transcription factor, DNA-bindingsearch Immunoglobulin-like foldsearch Immunoglobulin E-setsearch Beta-trefoil DNA-binding domainsearch LAG1, DNA bindingsearch
D