3bqr Summary

pdbe.org/3bqr
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Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with an imidazo-pyridazine ligand

A publication describing this structure is not available. The depositing authors are Filippakopoulos, P.search; Rellos, P.search; Fedorov, O.search; Niesen, F.search; Pike, A.C.W.search; Pilka, E.S.search; von Delft, F.search; Arrowsmith, C.H.search; Edwards, A.M.search; Weigelt, J.search; Knapp, S.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Death-associated protein kinase 3. This molecule has the UniProt identifier O43293 (DAPK3_HUMAN)search. The sample contained 283 residues which is < 90% of the natural sequence. Out of 283 residues 270 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Death-associated protein kinase 3 O43293 (9-289) (DAPK3_HUMAN)search Homo sapienssearch < 90% 283 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O43293 (9 - 289) Death-associated protein kinase 3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O43293) transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Myosin light chain kinase-relatedsearch