3bqd Summary


Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

The structure was published by Suino-Powell, K., Xu, Y., Zhang, C., et al., Tolbert, W.D., Simons, S.S., and Xu, H.E., in 2008 in a paper entitled "Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Glucocorticoid receptor and Nuclear receptor coactivator 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucocorticoid receptor P04150 (525-777) (GCR_HUMAN)search Homo sapienssearch < 90% 255 99%
B Nuclear receptor coactivator 1 Q15788 (1429-1441) (NCOA1_HUMAN)search Homo sapienssearch < 90% 13 84%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04150 (525 - 777) Glucocorticoid receptor Homo sapiens
Q15788 (1429 - 1441) Nuclear receptor coactivator 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P04150) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch