3bpt Summary


Crystal structure of human beta-hydroxyisobutyryl-CoA hydrolase in complex with quercetin

A publication describing this structure is not available. The depositing authors are Pilka, E.S.search; Phillips, C.search; King, O.N.F.search; Guo, K.search; von Delft, F.search; Pike, A.C.W.search; Arrowsmith, C.H.search; Weigelt, J.search; Edwards, A.M.search; Oppermann, U.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 3-hydroxyisobutyryl-CoA hydrolase. This molecule has the UniProt identifier Q6NVY1 (HIBCH_HUMAN)search. The sample contained 363 residues which is 92% of the natural sequence. Out of 363 residues 358 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 3-hydroxyisobutyryl-CoA hydrolase Q6NVY1 (32-386) (HIBCH_HUMAN)search Homo sapienssearch 92% 363 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q6NVY1 (32 - 386) 3-hydroxyisobutyryl-CoA hydrolase Homo sapiens

Chain Sequence family (Pfam)
A (Q6NVY1) PF13766: 2-enoyl-CoA Hydratase C-terminal regionsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q6NVY1) extracellular vesicular exosomesearch mitochondrionsearch mitochondrial matrixsearch branched-chain amino acid catabolic processsearch cellular nitrogen compound metabolic processsearch small molecule metabolic processsearch valine catabolic processsearch 3-hydroxyisobutyryl-CoA hydrolase activitysearch hydrolase activitysearch

Chain InterPro annotation
A Crontonase, C-terminalsearch ClpP/crotonase-like domainsearch