3bps Summary


PCSK9:EGF-A complex

The structure was published by Kwon, H.J., Lagace, T.A., McNutt, M.C., Horton, J.D., and Deisenhofer, J., in 2008 in a paper entitled "Molecular basis for LDL receptor recognition by PCSK9." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.41 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Proprotein convertase subtilisin/kexin type 9 and Low-density lipoprotein receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
P Proprotein convertase subtilisin/kexin type 9 Q8NBP7 (53-152) (PCSK9_HUMAN)search Homo sapienssearch < 90% 100 92%
A Proprotein convertase subtilisin/kexin type 9 Q8NBP7 (153-692) (PCSK9_HUMAN)search Homo sapienssearch < 90% 540 80%
E Low-density lipoprotein receptor P01130 (314-393) (LDLR_HUMAN)search Homo sapienssearch < 90% 83 49%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8NBP7 (53 - 152) Proprotein convertase subtilisin/kexin type 9 Homo sapiens
P01130 (314 - 393) Low-density lipoprotein receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
P Peptidase inhibitor I9search
A Subtilase familysearch
E EGF-type modulesearch Lamininsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q8NBP7) serine-type endopeptidase activitysearch proteolysissearch
E (P01130) calcium ion bindingsearch

Chain InterPro annotation
P Proteinase inhibitor, propeptidesearch Peptidase S8 propeptide/proteinase inhibitor I9search Peptidase S8, subtilisin-relatedsearch
A Peptidase S8/S53 domainsearch Peptidase S8, subtilisin-relatedsearch
E EGF-type aspartate/asparagine hydroxylation sitesearch Epidermal growth factor-like domainsearch EGF-like calcium-binding domainsearch Insulin-like growth factor binding protein, N-terminalsearch EGF-like, conserved sitesearch EGF-like calcium-binding, conserved sitesearch