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Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol

The structure was published by Baumli, S., Lolli, G., Lowe, E.D., et al., Debreczeni, J.E., Knapp, S., and Johnson, L.N., in 2008 in a paper entitled "The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cell division protein kinase 9 and Cyclin-T1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 9 P50750 (2-330) (CDK9_HUMAN)search Homo sapienssearch 93% 331 90%
B Cyclin-T1 O60563 (2-259) (CCNT1_HUMAN)search Homo sapienssearch < 90% 260 96%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P50750 (2 - 330) Cell division protein kinase 9 Homo sapiens
O60563 (2 - 259) Cyclin-T1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P50750) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P50750) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch
B (O60563) protein kinase bindingsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch transcription, DNA-templatedsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B Cyclin, N-terminalsearch Cyclin-likesearch Cyclin C/H/T/Lsearch Cyclin-T1search