Tesis ACE co-crystal structure with ketone ACE inhibitor kAF
The structure was published by Watermeyer, J.M., Kroger, W.L., O'Neill, H.G., Sewell, B.T., and Sturrock, E.D., in 2008 in a paper entitled "Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.17 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Angiotensin-converting enzyme, somatic isoform. This molecule has the UniProt identifier P12821 (ACE_HUMAN). The sample contained 591 residues which is < 90% of the natural sequence. Out of 591 residues 586 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: