Wee1 kinase complex with inhibitor PD352396
The structure was published by Smaill, J.B., Lee, H.H., Palmer, B.D., et al., Kraker, A., Hook, K., and Denny, W.A., in 2008 in a paper entitled "Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Wee1-like protein kinase. This molecule has the UniProt identifier P30291 (WEE1_HUMAN). The sample contained 287 residues which is < 90% of the natural sequence. Out of 287 residues 254 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: