3bhy Summary


Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with a beta-carboline ligand

The structure was published by Huber, K., Brault, L., Fedorov, O., et al., Schwaller, J., Knapp, S., and Bracher, F., in 2012 in a paper entitled "7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.24 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Death-associated protein kinase 3. This molecule has the UniProt identifier O43293 (DAPK3_HUMAN)search. The sample contained 283 residues which is < 90% of the natural sequence. Out of 283 residues 260 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Death-associated protein kinase 3 O43293 (9-289) (DAPK3_HUMAN)search Homo sapienssearch < 90% 283 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O43293 (9 - 289) Death-associated protein kinase 3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O43293) ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Myosin light chain kinase-relatedsearch