Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with a beta-carboline ligand
The structure was published by Huber, K., Brault, L., Fedorov, O., et al., Schwaller, J., Knapp, S., and Bracher, F., in 2012 in a paper entitled "7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.24 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Death-associated protein kinase 3. This molecule has the UniProt identifier O43293 (DAPK3_HUMAN). The sample contained 283 residues which is < 90% of the natural sequence. Out of 283 residues 260 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: