3bet Summary


Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution

The structure was published by Leese, M.P., Jourdan, F.L., Gaukroger, K., et al., Purohit, A., Reed, M.J., and Potter, B.V., in 2008 in a paper entitled "Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) myelin sheathsearch cytoplasmsearch cytosolsearch apical part of cellsearch plasma membranesearch basolateral plasma membranesearch extracellular vesicular exosomesearch axonsearch membranesearch extracellular spacesearch microvillussearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch regulation of intracellular pHsearch response to pHsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch one-carbon metabolic processsearch positive regulation of bone resorptionsearch regulation of anion transportsearch response to estrogensearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch response to organic substancesearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch