X-ray structure of EGFR in complex with oxime inhibitor
The structure was published by Xu, G., Searle, L.L., Hughes, T.V., et al., Fuentes-Pesquera, A.R., Middleton, S.A., and Greenberger, L.M., in 2008 in a paper entitled "Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Epidermal growth factor receptor. This molecule has the UniProt identifier P00533 (EGFR_HUMAN). The sample contained 315 residues which is < 90% of the natural sequence. Out of 315 residues 279 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: