3bej Summary


Structure of human FXR in complex with MFA-1 and co-activator peptide

The structure was published by Soisson, S.M., Parthasarathy, G., Adams, A.D., et al., Sparrow, C., Cui, J., and Becker, J.W., in 2008 in a paper entitled "Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Bile acid receptor and Nuclear receptor coactivator 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Bile acid receptor Q96RI1 (249-486) (NR1H4_HUMAN)search Homo sapienssearch < 90% 238 95%
B Bile acid receptor Q96RI1 (249-486) (NR1H4_HUMAN)search Homo sapienssearch < 90% 238 95%
E Nuclear receptor coactivator 1 Q15788 (676-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 25 48%
F Nuclear receptor coactivator 1 Q15788 (676-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 25 48%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q96RI1 (249 - 486) Bile acid receptor Homo sapiens
Q15788 (676 - 700) Nuclear receptor coactivator 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
E, F Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q96RI1) DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch
E, F (Q15788) ligand-dependent nuclear receptor transcription coactivator activitysearch histone acetyltransferase activitysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
E, F Nuclear receptor coactivator Src-1search Steroid receptor coactivatorsearch Nuclear receptor coactivatorsearch Nuclear receptor coactivator 1search