Structure of human FXR in complex with MFA-1 and co-activator peptide
The structure was published by Soisson, S.M., Parthasarathy, G., Adams, A.D., et al., Sparrow, C., Cui, J., and Becker, J.W., in 2008 in a paper entitled "Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely Bile acid receptor and Nuclear receptor coactivator 1.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterotetramers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 2 unique UniProt proteins: