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Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2

Source organism: Homo sapiens
Biochemical function: RNA binding
Biological process: protein phosphorylation
Cellular component: not assigned

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EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. SRSF protein kinase 1
The deposited structure of PDB entry 3beg contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in SRSF protein kinase 1. Showing 2 copies in chain A.

PF00076
Domain description: RNA recognition motif
Occurring in:
  1. Serine/arginine-rich splicing factor 1
The deposited structure of PDB entry 3beg contains 1 copy of Pfam domain PF00076 (RNA recognition motif) in Serine/arginine-rich splicing factor 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000504
Domain description: RNA recognition motif domain
Occurring in:
  1. Serine/arginine-rich splicing factor 1
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. SRSF protein kinase 1
IPR012677
Domain description: Nucleotide-binding alpha-beta plait domain superfamily
Occurring in:
  1. Serine/arginine-rich splicing factor 1
IPR035979
Domain description: RNA-binding domain superfamily
Occurring in:
  1. Serine/arginine-rich splicing factor 1
IPR029538
Domain description: Serine/arginine-rich splicing factor 1, RNA recognition motif 2
Occurring in:
  1. Serine/arginine-rich splicing factor 1
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. SRSF protein kinase 1
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. SRSF protein kinase 1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. SRSF protein kinase 1

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. SRSF protein kinase 1
The deposited structure of PDB entry 3beg contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in SRSF protein kinase 1. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. SRSF protein kinase 1
The deposited structure of PDB entry 3beg contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in SRSF protein kinase 1. Showing 1 copy in chain A.
3.30.70.330
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. Serine/arginine-rich splicing factor 1
The deposited structure of PDB entry 3beg contains 1 copy of CATH domain 3.30.70.330 (Alpha-Beta Plaits) in Serine/arginine-rich splicing factor 1. Showing 1 copy in chain B.
SCOP SCOP annotation
54929
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: RNA-binding domain, RBD
Occurring in:
  1. Serine/arginine-rich splicing factor 1
The deposited structure of PDB entry 3beg contains 1 copy of SCOP domain 54929 (Canonical RBD) in Serine/arginine-rich splicing factor 1. Showing 1 copy in chain B.

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