Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2
The structure was published by Bostrom, J., Yu, S.F., Kan, D., et al., Ross, S., Wiesmann, C., and Fuh, G., in 2009 in a paper entitled "Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 3 biomacromolecules, namely Receptor tyrosine-protein kinase erbB-2, Fab Fragment-Heavy Chain, and Fab Fragment-Light Chain.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterotrimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: