3be1 Summary

pdbe.org/3be1
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Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2

The structure was published by Bostrom, J., Yu, S.F., Kan, D., et al., Ross, S., Wiesmann, C., and Fuh, G., in 2009 in a paper entitled "Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Receptor tyrosine-protein kinase erbB-2, Fab Fragment-Heavy Chain, and Fab Fragment-Light Chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Receptor tyrosine-protein kinase erbB-2 P04626 (23-646) (ERBB2_HUMAN)search Homo sapienssearch < 90% 624 93%
H Fab Fragment-Heavy Chain Not available
Homo sapienssearch Not available 230 92%
L Fab Fragment-Light Chain Not available
Homo sapienssearch Not available 218 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04626 (23 - 646) Receptor tyrosine-protein kinase erbB-2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2search Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch
H Immunoglobulinssearch
L Immunoglobulinssearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P04626) membranesearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch protein phosphorylationsearch ATP bindingsearch transmembrane receptor protein tyrosine kinase activitysearch

Chain InterPro annotation
A EGF receptor, L domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch
H Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
L Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch