› 3bce

X-ray diffraction
2.5Å resolution

Crystal structure of the ErbB4 kinase

Released:
DOI: 10.2210/pdb3bce/pdb
PDB entry 3bce coloured by chain, front view.
PDB entry 3bce coloured by chain, side view.
PDB entry 3bce coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ
Structure 16 460-7 (2008)
PMID: 18334220

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172255 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ERBB4 intracellular domain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 328 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15303 (Residues: 702-1029; Coverage: 26%)
Gene names: ERBB4, HER4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MN 1 x MN
Ligand PG4 1 x PG4
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P32
Unit cell:
a: 86.723Å b: 86.723Å c: 120.008Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.251
Expression system: Spodoptera frugiperda

Quick links

Citations

29 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
28 more

12 mentions without citation

Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Qiu et al. (2008)
11 more