3b6r Summary


Crystal structure of Human Brain-type Creatine Kinase

The structure was published by Bong, S.M., Moon, J.H., Nam, K.H., Lee, K.S., Chi, Y.M., and Hwang, K.Y., in 2008 in a paper entitled "Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Creatine kinase B-type.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Creatine kinase B-type P12277 (1-381) (KCRB_HUMAN)search Homo sapienssearch 100% 381 98%
B Creatine kinase B-type P12277 (1-381) (KCRB_HUMAN)search Homo sapienssearch 100% 381 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12277 (1 - 381) Creatine kinase B-type Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P12277) Transferase Creatine Kinase, Chain A, domain 1search, Glutamine synthetase/guanido kinasesearch PF00217: ATP:guanido phosphotransferase, C-terminal catalytic domainsearch, PF02807: ATP:guanido phosphotransferase, N-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P12277) nucleotide bindingsearch catalytic activitysearch creatine kinase activitysearch protein bindingsearch ATP bindingsearch kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch cytoplasmsearch mitochondrionsearch cytosolsearch extracellular vesicular exosomesearch creatine metabolic processsearch brain developmentsearch phosphorylationsearch substantia nigra developmentsearch cellular chloride ion homeostasissearch cellular nitrogen compound metabolic processsearch small molecule metabolic processsearch

Chain InterPro annotation
A, B ATP:guanido phosphotransferasesearch Glutamine synthetase/guanido kinase, catalytic domainsearch ATP:guanido phosphotransferase, N-terminalsearch ATP:guanido phosphotransferase, catalytic domainsearch ATP:guanido phosphotransferase active sitesearch