3b36 Summary


Structure of M26L DJ-1

The structure was published by Lakshminarasimhan, M., Maldonado, M.T., Zhou, W., Fink, A.L., and Wilson, M.A., in 2008 in a paper entitled "Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein DJ-1. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 192 residues which is 100% of the natural sequence. Out of 192 residues 187 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 192 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) Protein DJ-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q99497) mitochondrionsearch cytosolsearch nucleussearch mitochondrial respiratory chain complex Isearch extracellular vesicular exosomesearch PML bodysearch neuron projectionsearch cytoplasmsearch chromatinsearch mitochondrial intermembrane spacesearch plasma membranesearch membrane raftsearch cell bodysearch axonsearch membranesearch mitochondrial matrixsearch regulation of neuron apoptotic processsearch cellular response to reactive oxygen speciessearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch negative regulation of gene expressionsearch positive regulation of peptidyl-serine phosphorylationsearch protein deglycosylationsearch cellular response to glyoxalsearch positive regulation of oxidative phosphorylation uncoupler activitysearch negative regulation of oxidative stress-induced neuron deathsearch positive regulation of transcription from RNA polymerase II promotersearch hydrogen peroxide metabolic processsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch single fertilizationsearch regulation of fibril organizationsearch negative regulation of hydrogen peroxide-induced neuron deathsearch adult locomotory behaviorsearch membrane hyperpolarizationsearch positive regulation of sequence-specific DNA binding transcription factor activitysearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch synaptic transmission, dopaminergicsearch negative regulation of neuron deathsearch negative regulation of extrinsic apoptotic signaling pathwaysearch positive regulation of superoxide dismutase activitysearch detoxification of mercury ionsearch protein stabilizationsearch negative regulation of protein ubiquitinationsearch mitochondrion organizationsearch cellular response to oxidative stresssearch autophagysearch positive regulation of protein kinase B signalingsearch negative regulation of protein kinase activitysearch membrane depolarizationsearch negative regulation of ubiquitin-specific protease activitysearch regulation of TRAIL receptor biosynthetic processsearch glycolate biosynthetic processsearch cellular response to hydrogen peroxidesearch positive regulation of gene expressionsearch negative regulation of neuron apoptotic processsearch positive regulation of protein localization to nucleussearch negative regulation of cell deathsearch negative regulation of protein bindingsearch negative regulation of protein sumoylationsearch negative regulation of apoptotic processsearch negative regulation of oxidative stress-induced cell deathsearch positive regulation of L-dopa biosynthetic processsearch dopamine uptake involved in synaptic transmissionsearch negative regulation of protein acetylationsearch regulation of androgen receptor signaling pathwaysearch negative regulation of proteasomal ubiquitin-dependent protein catabolic processsearch negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathwaysearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch positive regulation of protein homodimerization activitysearch positive regulation of dopamine biosynthetic processsearch negative regulation of death-inducing signaling complex assemblysearch proteolysissearch activation of protein kinase B activitysearch response to hydrogen peroxidesearch enzyme active site formation via L-cysteine sulfinic acidsearch positive regulation of tyrosine 3-monooxygenase activitysearch negative regulation of hydrogen peroxide-induced cell deathsearch negative regulation of ubiquitin-protein transferase activitysearch Ras protein signal transductionsearch positive regulation of androgen receptor activitysearch methylglyoxal catabolic process to D-lactatesearch negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaysearch negative regulation of protein export from nucleussearch glyoxal catabolic processsearch positive regulation of interleukin-8 productionsearch regulation of mitochondrial membrane potentialsearch regulation of inflammatory responsesearch detoxification of copper ionsearch positive regulation of pyrroline-5-carboxylate reductase activitysearch positive regulation of L-dopa decarboxylase activitysearch negative regulation of protein catabolic processsearch lactate biosynthetic processsearch negative regulation of protein K48-linked deubiquitinationsearch oxidation-reduction processsearch inflammatory responsesearch positive regulation of transcription regulatory region DNA bindingsearch negative regulation of protein phosphorylationsearch RNA bindingsearch protein homodimerization activitysearch glyoxalase (glycolic acid-forming) activitysearch cuprous ion bindingsearch ubiquitin-like protein conjugating enzyme bindingsearch protein bindingsearch transcription coactivator activitysearch peptidase activitysearch enzyme bindingsearch repressing transcription factor bindingsearch mRNA bindingsearch scaffold protein bindingsearch L-dopa decarboxylase activator activitysearch ubiquitin-specific protease bindingsearch identical protein bindingsearch androgen receptor bindingsearch mercury ion bindingsearch glyoxalase III activitysearch hydrolase activitysearch small protein activating enzyme bindingsearch receptor bindingsearch transcription factor bindingsearch copper ion bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch peroxiredoxin activitysearch double-stranded DNA bindingsearch kinase bindingsearch core promoter bindingsearch superoxide dismutase copper chaperone activitysearch tyrosine 3-monooxygenase activator activitysearch cupric ion bindingsearch single-stranded DNA bindingsearch cytokine bindingsearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch