3b07 Summary

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Crystal structure of octameric pore form of gamma-hemolysin from Staphylococcus aureus

The structure was published by Yamashita, K., Kawai, Y., Tanaka, Y., et al., Kamio, Y., Yao, M., and Tanaka, I., in 2011 in a paper entitled "Crystal structure of the octameric pore of staphylococcal gamma-hemolysin reveals the beta-barrel pore formation mechanism by two components" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.495 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Gamma-hemolysin component B and Gamma-hemolysin component A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Gamma-hemolysin component B Q931F3 (27-325) (Q931F3_STAAM)search Staphylococcus aureus subsp. aureus Mu50search 92% 309 91%
C Gamma-hemolysin component B Q931F3 (27-325) (Q931F3_STAAM)search Staphylococcus aureus subsp. aureus Mu50search 92% 309 91%
E Gamma-hemolysin component B Q931F3 (27-325) (Q931F3_STAAM)search Staphylococcus aureus subsp. aureus Mu50search 92% 309 91%
G Gamma-hemolysin component B Q931F3 (27-325) (Q931F3_STAAM)search Staphylococcus aureus subsp. aureus Mu50search 92% 309 91%
B Gamma-hemolysin component A P0A071 (30-309) (HLGA_STAAM)search Staphylococcus aureus subsp. aureus Mu50search 96% 290 93%
D Gamma-hemolysin component A P0A071 (30-309) (HLGA_STAAM)search Staphylococcus aureus subsp. aureus Mu50search 96% 290 93%
F Gamma-hemolysin component A P0A071 (30-309) (HLGA_STAAM)search Staphylococcus aureus subsp. aureus Mu50search 96% 290 93%
H Gamma-hemolysin component A P0A071 (30-309) (HLGA_STAAM)search Staphylococcus aureus subsp. aureus Mu50search 96% 290 93%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q931F3 (27 - 325) Gamma-hemolysin component B Staphylococcus aureus subsp. aureus Mu50
P0A071 (30 - 309) Gamma-hemolysin component A Staphylococcus aureus subsp. aureus Mu50

Chain Structural classification (CATH) Sequence family (Pfam)
A, C, E, G Leukocidin-likesearch Leukocidin/Hemolysin toxin familysearch
B, D, F, H (P0A071) Leukocidin-likesearch PF07968: Leukocidin/Hemolysin toxin familysearch

Chain ID Cellular component (GO) Biological process (GO)
A, C, E, G (Q931F3) extracellular regionsearch cytolysis in other organismsearch pathogenesissearch
B, D, F, H (P0A071) extracellular regionsearch pathogenesissearch hemolysis in other organismsearch cytolysissearch cytolysis in other organismsearch

Chain InterPro annotation
A, C, E, G Bi-component toxin, staphylococcisearch Leukocidin/porinsearch
B, D, F, H Bi-component toxin, staphylococcisearch Leukocidin/porinsearch