› 3ar2

X-ray diffraction
2.5Å resolution

Calcium pump crystal structure with bound AMPPCP and Ca2+

Released:
DOI: 10.2210/pdb3ar2/pdb
PDB entry 3ar2 coloured by chain, front view.
PDB entry 3ar2 coloured by chain, side view.
PDB entry 3ar2 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+.
Toyoshima C, Yonekura S, Tsueda J, Iwasawa S
Proc Natl Acad Sci U S A 108 1833-8 (2011)
PMID: 21239683

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

4 bound ligands:
Ligand CA 3 x CA
Ligand ACP 1 x ACP
Ligand NA 1 x NA
Ligand PC1 1 x PC1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 161.995Å b: 75.306Å c: 151.541Å
α: 90° β: 108.97° γ: 90°
R-values:
R R work R free
0.248 0.247 0.272

Quick links

Citations

6 review citations

Ion pathways in the sarcoplasmic reticulum Ca2+-ATPase.
Bublitz et al. (2013)
5 more

10 mentions without citation

Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.
Ushioda et al. (2016)
9 more