› 3amy

X-ray diffraction
2.3Å resolution

Crystal structure of human CK2 alpha complexed with apigenin

Released:
DOI: 10.2210/pdb3amy/pdb
PDB entry 3amy coloured by chain, front view.
PDB entry 3amy coloured by chain, side view.
PDB entry 3amy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sekiguchi Y, Nakaniwa T, Kinoshita T, Tada T

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 40.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand AGI 1 x AGI
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 48.63Å b: 73.03Å c: 77.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.269 0.267 0.34
Expression system: Escherichia coli

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