› 3al9

X-ray diffraction
2.1Å resolution

Mouse Plexin A2 extracellular domain

Released:
DOI: 10.2210/pdb3al9/pdb
PDB entry 3al9 coloured by chain, front view.
PDB entry 3al9 coloured by chain, side view.
PDB entry 3al9 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for semaphorin signalling through the plexin receptor.
Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J
Nature 467 1123-7 (2010)
PMID: 20881961

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159714 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plexin-A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 539 amino acids
Theoretical weight: 60.19 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P70207 (Residues: 31-561; Coverage: 28%)
Gene names: Kiaa0463, Plxna2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 3 x EDO
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P1
Unit cell:
a: 55.702Å b: 60.677Å c: 95.385Å
α: 109.8° β: 92.47° γ: 112.53°
R-values:
R R work R free
0.208 0.205 0.257
Expression system: Homo sapiens

Quick links

Citations

43 review citations

Getting neural circuits into shape with semaphorins.
Pasterkamp RJ. (2012)
42 more

5 mentions without citation

Structural Basis for Plexin Activation and Regulation.
Kong et al. (2016)
4 more