3agl Summary


Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1039

The structure was published by Pflug, A., Rogozina, J., Lavogina, D., et al., Uri, A., Engh, R.A., and Bossemeyer, D., in 2010 in a paper entitled "Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of cAMP-dependent protein kinase catalytic subunit alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cAMP-dependent protein kinase catalytic subunit alpha P17612 (1-351) (KAPCA_HUMAN)search Homo sapienssearch 96% 351 97%
B cAMP-dependent protein kinase catalytic subunit alpha Not available
Homo sapienssearch 100% 351 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P17612 (1 - 351) cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P17612) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P17612) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch cAMP-dependent protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase bindingsearch nucleotide bindingsearch ubiquitin protein ligase bindingsearch transferase activitysearch protein serine/threonine/tyrosine kinase activitysearch kinase activitysearch protein phosphorylationsearch phosphorylationsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch water transportsearch signal transductionsearch activation of protein kinase A activitysearch protein autophosphorylationsearch regulation of cardiac muscle contractionsearch mesoderm formationsearch peptidyl-serine phosphorylationsearch energy reserve metabolic processsearch cellular response to glucose stimulussearch small molecule metabolic processsearch carbohydrate metabolic processsearch cytosolic calcium ion homeostasissearch innate immune responsesearch activation of phospholipase C activitysearch sperm capacitationsearch G2/M transition of mitotic cell cyclesearch epidermal growth factor receptor signaling pathwaysearch transmembrane transportsearch peptidyl-threonine phosphorylationsearch glucose metabolic processsearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch calcium-mediated signaling using intracellular calcium sourcesearch blood coagulationsearch positive regulation of cell cycle arrestsearch regulation of protein processingsearch mitotic cell cyclesearch regulation of proteasomal protein catabolic processsearch regulation of heart ratesearch cellular response to parathyroid hormone stimulussearch cell communication by electrical coupling involved in cardiac conductionsearch regulation of osteoblast differentiationsearch cellular response to glucagon stimulussearch triglyceride catabolic processsearch neural tube closuresearch regulation of tight junction assemblysearch fibroblast growth factor receptor signaling pathwaysearch gluconeogenesissearch positive regulation of protein export from nucleussearch regulation of synaptic transmissionsearch intracellular signal transductionsearch regulation of protein bindingsearch neurotrophin TRK receptor signaling pathwaysearch cellular response to epinephrine stimulussearch regulation of insulin secretionsearch nucleussearch ciliumsearch cytosolsearch membranesearch mitochondrionsearch plasma membranesearch cytoplasmsearch cell projectionsearch ciliary basesearch calcium channel complexsearch motile ciliumsearch centrosomesearch cAMP-dependent protein kinase complexsearch extracellular vesicular exosomesearch neuromuscular junctionsearch

Chain InterPro annotation
A, B Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch