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Crystal structure of imidazo pyrimidine derivative bound to the kinase domain of human LCK, (Auto-phosphorylated on TYR394)

X-ray diffraction
2.2Å resolution
PDB entry 3acj coloured by chain, front view.
PDB entry 3acj coloured by chain, side view.
PDB entry 3acj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Lck
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Multimeric state: monomeric
Accessible surface area: 14019.83 Å2
Buried surface area: 502.2 Å2
Dissociation area: 126.27 Å2
Dissociation energy (ΔGdiss): -2.02 kcal/mol
Dissociation entropy (TΔSdiss): 0.24 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138948

Macromolecules

Tyrosine-protein kinase Lck
Chain: A
Length: 285 amino acids
Theoretical weight: 33.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06239 (Residues: 225-509; Coverage: 56%)
Gene name: LCK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase Lck in PDB entry 3acj, assembly 1, front view.
Tyrosine-protein kinase Lck in PDB entry 3acj, assembly 1, side view.
Tyrosine-protein kinase Lck in PDB entry 3acj, assembly 1, top view.
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