3acc Summary

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PDB entry 3acc (supersedes 2ywt)

Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with GMP from Thermus thermophilus HB8

The structure was published by Kanagawa, M., Baba, S., Ebihara, A., et al., Kuramitsu, S., Sampei, G., and Kawai, G., in 2010 in a paper entitled "Structures of hypoxanthine-guanine phosphoribosyltransferase (TTHA0220) from Thermus thermophilus HB8." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.16 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Hypoxanthine-guanine phosphoribosyltransferase. This molecule has the UniProt identifier Q5SLS3 (Q5SLS3_THET8)search. The sample contained 181 residues which is 100% of the natural sequence. Out of 181 residues 166 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hypoxanthine-guanine phosphoribosyltransferase Q5SLS3 (1-181) (Q5SLS3_THET8)search Thermus thermophilus HB8search 100% 181 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q5SLS3 (1 - 181) Hypoxanthine-guanine phosphoribosyltransferase Thermus thermophilus HB8

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q5SLS3) Rossmann foldsearch PF00156: Phosphoribosyl transferase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q5SLS3) transferase activitysearch hypoxanthine phosphoribosyltransferase activitysearch transferase activity, transferring glycosyl groupssearch purine ribonucleoside salvagesearch nucleoside metabolic processsearch cytoplasmsearch

Chain InterPro annotation
A Phosphoribosyltransferase domainsearch Hypoxanthine phosphoribosyl transferasesearch Phosphoribosyltransferase-likesearch