Structure of PIM-1 kinase crystallized in the presence of P27KIP1 Carboxy-terminal peptide
The structure was published by Morishita, D., Takami, M., Yoshikawa, S., et al., Sekimizu, K., Yokoyama, S., and Fujita, N., in 2011 in a paper entitled "Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN). The sample contained 320 residues which is < 90% of the natural sequence. Out of 320 residues 273 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: