3a8x Summary

pdbe.org/3a8x
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Crystal Structure of PKCiota kinase domain

The structure was published by Takimura, T., Kamata, K., Fukasawa, K., et al., Takahashi, I., Kotani, H., and Iwasawa, Y., in 2010 in a paper entitled "Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein kinase C iota type.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein kinase C iota type P41743 (249-588) (KPCI_HUMAN)search Homo sapienssearch < 90% 345 97%
B Protein kinase C iota type P41743 (249-588) (KPCI_HUMAN)search Homo sapienssearch < 90% 345 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P41743 (249 - 588) Protein kinase C iota type Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P41743) ATP bindingsearch protein serine/threonine kinase activitysearch zinc ion bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase C, zeta/iotasearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch