3a8x Summary


Crystal Structure of PKCiota kinase domain

The structure was published by Takimura, T., Kamata, K., Fukasawa, K., et al., Takahashi, I., Kotani, H., and Iwasawa, Y., in 2010 in a paper entitled "Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein kinase C iota type.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein kinase C iota type P41743 (249-588) (KPCI_HUMAN)search Homo sapienssearch < 90% 345 97%
B Protein kinase C iota type P41743 (249-588) (KPCI_HUMAN)search Homo sapienssearch < 90% 345 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P41743 (249 - 588) Protein kinase C iota type Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P41743) protein phosphorylationsearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch zinc ion bindingsearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase Csearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch