3a62 Summary

pdbe.org/3a62
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Crystal structure of phosphorylated p70S6K1

The structure was published by Sunami, T., Byrne, N., Diehl, R.E., et al., Lumb, K.J., Munshi, S.K., and Sharma, S., in 2010 in a paper entitled "Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Ribosomal protein S6 kinase beta-1. This molecule has the UniProt identifier P23443 (KS6B1_HUMAN)search. The sample contained 327 residues which is < 90% of the natural sequence. Out of 327 residues 264 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ribosomal protein S6 kinase beta-1 P23443 (75-399) (KS6B1_HUMAN)search Homo sapienssearch < 90% 327 80%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23443 (75 - 399) Ribosomal protein S6 kinase beta-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P23443) transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch