› 3a0k

X-ray diffraction
1.8Å resolution

Crystal structure of an antiflamatory legume lectin from Cymbosema roseum seeds

Released:
DOI: 10.2210/pdb3a0k/pdb
PDB entry 3a0k coloured by chain, front view.
PDB entry 3a0k coloured by chain, side view.
PDB entry 3a0k coloured by chain, top view.
Source organism: Cymbosema roseum
Primary publication:
Structural basis for both pro- and anti-inflammatory response induced by mannose-specific legume lectin from Cymbosema roseum.
Rocha BA, Delatorre P, Oliveira TM, Benevides RG, Pires AF, Sousa AA, Souza LA, Assreuy AM, Debray H, de Azevedo WF, Sampaio AH, Cavada BS
Biochimie 93 806-16 (2011)
PMID: 21277932

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112709 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Legume lectin domain-containing protein Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 237 amino acids
Theoretical weight: 25.31 KDa
Source organism: Cymbosema roseum
UniProt:
  • Canonical: D5MNX4 (Residues: 1-237; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand MN 4 x MN
Ligand CA 4 x CA
Ligand ABA 2 x ABA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 68.034Å b: 103.074Å c: 122.334Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.235

Quick links

Citations

3 review citations

Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties.
Barre et al. (2019)
2 more

1 mention without citation

ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships.
Cavada et al. (2018)