3a06

X-ray diffraction
2Å resolution

Crystal structure of DXR from Thermooga maritia, in complex with fosmidomycin and NADPH

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-194660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-deoxy-D-xylulose 5-phosphate reductoisomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 376 amino acids
Theoretical weight: 42.26 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WZZ1 (Residues: 1-376; Coverage: 100%)
Gene names: TM_0889, dxr
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NDP 3 x NDP
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P43
Unit cell:
a: 108.622Å b: 108.622Å c: 74.662Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.24
Expression system: Escherichia coli