› 3x1i

X-ray diffraction
2.4Å resolution

hPPARgamma Ligand binding domain in complex with 6-oxo-tetracosahexaenoic acid

Released:
DOI: 10.2210/pdb3x1i/pdb
PDB entry 3x1i coloured by chain, front view.
PDB entry 3x1i coloured by chain, side view.
PDB entry 3x1i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Characterization of covalent bond formation between PPARγ and oxo-fatty acids.
Egawa D, Itoh T, Yamamoto K
Bioconjug Chem 26 690-8 (2015)
PMID: 25785518

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 232-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 66B 2 x 66B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: C2
Unit cell:
a: 93.34Å b: 61.92Å c: 118.82Å
α: 90° β: 102.72° γ: 90°
R-values:
R R work R free
0.231 0.229 0.279
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The PPAR Ω Pocket: Renewed Opportunities for Drug Development.
Kaupang et al. (2020)
1 more