› 3wj4

X-ray diffraction
1.95Å resolution

Crystal structure of PPARgamma ligand binding domain in complex with tributyltin

Released:
DOI: 10.2210/pdb3wj4/pdb
PDB entry 3wj4 coloured by chain, front view.
PDB entry 3wj4 coloured by chain, side view.
PDB entry 3wj4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Harada S, Hiromori Y, Fukakusa S, Kawahara K, Nakamura S, Noda M, Uchiyama S, Fukui K, Nishikawa J, Nagase H, Kobayashi Y, Ohkubo T, Yoshida T, Nakanishi T

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand TBY 2 x TBY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P21
Unit cell:
a: 56.338Å b: 88.286Å c: 57.509Å
α: 90° β: 90.68° γ: 90°
R-values:
R R work R free
0.196 0.194 0.241
Expression system: Escherichia coli

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