› 3war

X-ray diffraction
1.04Å resolution

Crystal structure of human CK2a

Released:
DOI: 10.2210/pdb3war/pdb
PDB entry 3war coloured by chain, front view.
PDB entry 3war coloured by chain, side view.
PDB entry 3war coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human CK2α at 1.06 Å resolution.
Kinoshita T, Nakaniwa T, Sekiguchi Y, Sogabe Y, Sakurai A, Nakamura S, Nakanishi I
J Synchrotron Radiat 20 974-9 (2013)
PMID: 24121351

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 40.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NIO 1 x NIO
Ligand EDO 19 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 51.454Å b: 78.313Å c: 80.136Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.143 0.168
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

The protein kinase CK2(Andante) holoenzyme structure supports proposed models of autoregulation and trans-autophosphorylation.
Schnitzler et al. (2014)
1 more

14 mentions without citation

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.
Oshima et al. (2019)
13 more