› 3w4u

X-ray diffraction
1.95Å resolution

Human zeta-2 beta-2-s hemoglobin

Released:
DOI: 10.2210/pdb3w4u/pdb
PDB entry 3w4u coloured by chain, front view.
PDB entry 3w4u coloured by chain, side view.
PDB entry 3w4u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of fully liganded Hb ζ2β2s trapped in a tense conformation.
Safo MK, Ko TP, Abdulmalik O, He Z, Wang AH, Schreiter ER, Russell JE
Acta Crystallogr D Biol Crystallogr 69 2061-71 (2013)
PMID: 24100324

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135392 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit zeta Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 142 amino acids
Theoretical weight: 15.66 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P02008 (Residues: 1-142; Coverage: 100%)
Gene names: HBZ, HBZ2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 146 amino acids
Theoretical weight: 15.86 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand HEM 6 x HEM
Ligand CMO 6 x CMO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P3121
Unit cell:
a: 115.54Å b: 115.54Å c: 140.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.205 0.255
Expression system: Mus musculus

Quick links

Citations

1 review citation

Hemoglobin: Structure, Function and Allostery.
Ahmed et al. (2020)
1 other article

5 mentions without citation

A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Wei et al. (2014)
4 more