› 3vwv

X-ray diffraction
1.8Å resolution

crystal structure of N-terminally truncated peroxiredoxin 4 from M. musculus

Released:
DOI: 10.2210/pdb3vwv/pdb
PDB entry 3vwv coloured by chain, front view.
PDB entry 3vwv coloured by chain, side view.
PDB entry 3vwv coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding.
Sato Y, Kojima R, Okumura M, Hagiwara M, Masui S, Maegawa K, Saiki M, Horibe T, Suzuki M, Inaba K
Sci Rep 3 2456 (2013)
PMID: 23949117

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 23.61 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O08807 (Residues: 87-274; Coverage: 80%)
Gene name: Prdx4
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand 1PE 1 x 1PE
Ligand ACY 1 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: I4
Unit cell:
a: 104.321Å b: 104.321Å c: 84.228Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.155 0.153 0.193
Expression system: Escherichia coli

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Citations

30 review citations

Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum.
Hudson et al. (2015)
29 more