› 3v92

X-ray diffraction
2.74Å resolution

Function and Biology Details

Reaction catalysed: 
(1a) arachidonate + O(2) = (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polyunsaturated fatty acid 5-lipoxygenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 691 amino acids
Theoretical weight: 79.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09917 (Residues: 1-674; Coverage: 100%)
Gene names: ALOX5, LOG5
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FE2 2 x FE2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 55.191Å b: 202.375Å c: 76.986Å
α: 90° β: 109.91° γ: 90°
R-values:
R R work R free
0.186 0.183 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Mammalian lipoxygenases and their biological relevance.
Kuhn et al. (2015)
3 more

6 mentions without citation

Thiophene-Based Compounds with Potential Anti-Inflammatory Activity.
da Cruz et al. (2021)
5 more