› 3u92

X-ray diffraction
1.9Å resolution

Crystal structure of the GluK3 ligand binding domain complex with kainate and zinc: P2221 form

Released:
DOI: 10.2210/pdb3u92/pdb
PDB entry 3u92 coloured by chain, front view.
PDB entry 3u92 coloured by chain, side view.
PDB entry 3u92 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface.
Veran J, Kumar J, Pinheiro PS, Athané A, Mayer ML, Perrais D, Mulle C
Neuron 76 565-78 (2012)
PMID: 23141068

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154593 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.05 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42264 (Residues: 433-546, 669-807; Coverage: 29%)
Gene names: Glur7, Grik3
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand KAI 2 x KAI
Ligand ZN 8 x ZN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P2221
Unit cell:
a: 129.537Å b: 55.654Å c: 90.052Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.222
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
12 more

2 mentions without citation

Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface.
Veran et al. (2012)
1 more